Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills
نویسندگان
چکیده
منابع مشابه
Learning is necessary for training induced brain plasticity
Introduction. It is well established that brain structure is plastic and can reorganize in response to specific stimuli; however, it has only recently been recognized that these changes can manifest as volumetric differences detected on MRI [1-2]. We have previously shown in mice that five days of spatial memory training using a water-maze is sufficient to cause region specific local volume cha...
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Preliminary evidence indicates that dopamine given by mouth facilitates the learning of motor skills and improves the recovery of movement after stroke. The mechanism of these phenomena is unknown. Here, we describe a mechanism by demonstrating in rat that dopaminergic terminals and receptors in primary motor cortex (M1) enable motor skill learning and enhance M1 synaptic plasticity. Eliminatio...
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ژورنال
عنوان ژورنال: Nature
سال: 2012
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature10845